Bethke Cancer Center

Open Clinical Trials

Open trials through Commonwealth Hematology-Oncology

For more information on trials through Commonwealth Hematology-Oncology, Inc., please click on the following link: www.chomed.com/clinicaltrials.htm

Open trials through Radiation Oncology Therapy Group (RTOG)

RTOG 0413
A Randomized Phase III study of Conventional Whole Breast Irradiation (WBI) Versus Partial Breast Irradiation (PBI) For Women with Stage 0, I, or II Breast Cancer

This is a Phase III clinical trial. The main purpose of a Phase III clinical trial is to compare the study treatments with the treatment that is considered the standard of care. WBI is a standard treatment after a lumpectomy. The purpose of this study is to see if partial breast irradiation (PBI) is as good as or better than whole breast irradiation (WBI) in keeping cancer from coming back in the breast. Studies have shown that giving radiation therapy to the breast after lumpectomy helps keep cancer from coming back in the breast. WBI is radiation therapy given 5 days a week for 5 to 7 weeks to the whole breast. PBI is radiation therapy given only to the area of the breast where the cancer was removed (called the “tumor bed”), at a higher dose rate. PBI is given 2 times a day on 5 days, for a total of 10 treatment sessions. Since it treats only a small portion of the breast, PBI may be given over a period of 5 to 10 days.

RTOG 0712
A Phase II Randomized Study for Patients With Muscle-Invasive Bladder Cancer Evaluating Transurethral Surgery And Concomitant Chemoradiation By Either BID Irradiation Plus 5-Fluorouracil And Cisplatin Or QD Irradiation Plus Gemcitabine Followed By Selective Bladder Preservation And Gemcitabine/Cisplatin Adjuvant Chemotherapy

This is a phase II clinical trial. The purpose of this study is to find out what effects (good and/or bad) chemotherapy combined with external radiation therapy and possible removal of the bladder has on the patient and on the cancer. The chemotherapy drugs used in this study are not experimental drugs. These drugs have been used in the treatement of many patients with bladder cancer. This research is being done to see if one combination of drugs with radiation is superior to another in the treatment of this disease.

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	Bethke Cancer Center Open Clinical Trials Open trials through Commonwealth Hematology-Oncology For more information on trials through Commonwealth Hematology-Oncology, Inc., please click on the following link: www.chomed.com/clinicaltrials.htm Open trials through Radiation Oncology Therapy Group (RTOG) RTOG 0413 A Randomized Phase III study of Conventional Whole Breast Irradiation (WBI) Versus Partial Breast Irradiation (PBI) For Women with Stage 0, I, or II Breast Cancer This is a Phase III clinical trial. The main purpose of a Phase III clinical trial is to compare the study treatments with the treatment that is considered the standard of care. WBI is a standard treatment after a lumpectomy. The purpose of this study is to see if partial breast irradiation (PBI) is as good as or better than whole breast irradiation (WBI) in keeping cancer from coming back in the breast. Studies have shown that giving radiation therapy to the breast after lumpectomy helps keep cancer from coming back in the breast. WBI is radiation therapy given 5 days a week for 5 to 7 weeks to the whole breast. PBI is radiation therapy given only to the area of the breast where the cancer was removed (called the “tumor bed”), at a higher dose rate. PBI is given 2 times a day on 5 days, for a total of 10 treatment sessions. Since it treats only a small portion of the breast, PBI may be given over a period of 5 to 10 days. RTOG 0712 A Phase II Randomized Study for Patients With Muscle-Invasive Bladder Cancer Evaluating Transurethral Surgery And Concomitant Chemoradiation By Either BID Irradiation Plus 5-Fluorouracil And Cisplatin Or QD Irradiation Plus Gemcitabine Followed By Selective Bladder Preservation And Gemcitabine/Cisplatin Adjuvant Chemotherapy This is a phase II clinical trial. The purpose of this study is to find out what effects (good and/or bad) chemotherapy combined with external radiation therapy and possible removal of the bladder has on the patient and on the cancer. The chemotherapy drugs used in this study are not experimental drugs. These drugs have been used in the treatement of many patients with bladder cancer. This research is being done to see if one combination of drugs with radiation is superior to another in the treatment of this disease.